Table 4

Conserved microRNA target sites within the 3'-UTRs of each opsin in O. niloticus and M. zebra

Opsin

miRNA

Target

Conserved1

Function and expression

Ref(s)


SWS1

miR-725

TGACTGAG

GA

Expressed in fins

[55]

SWS2B

miR-217

ATGCAGTA

GA

Alters PTEN exp.; found in eye

[75,78]

SWS2A

miR-181a

AGAATGTA

DR

T-cell regulation; found in eye

[75,79]

RH2B

miR-23b

TATGTGAA

TR

Ganglion apoptosis; found in eye

[77,116]

RH2Aα/β

miR-96

TTGCCAAA

OL

Sensory organ specific; found in eye

[76,117]

miR-182a

TTGCCAAA

OL

Sensory organ specific; found in eye

[76,117]

LWS

miR-728

TTTAGTAA

GA,TN,TR

Unknown; found in eye

[55]

miR-722*

GCAAAAAA

TR

Unknown; found in eye

[55]


1 Other fish species in which this target site is also found: GA = stickleback (G. aculeatus), DR = zebrafish (D. rerio), TR = fugu (T. rubripes), TN = pufferfish (T. nigroviridis); OL = medaka (O. latipes)

* This site present in O. niloticus only

O'Quin et al. BMC Evolutionary Biology 2011 11:120   doi:10.1186/1471-2148-11-120

Open Data