Open Access Research article

The Mediterranean Sea as a barrier to gene flow: evidence from variation in and around the F7 and F12 genomic regions

Georgios Athanasiadis1, Emili González-Pérez1, Esther Esteban1, Jean-Michel Dugoujon2, Mark Stoneking3 and Pedro Moral1*

Author Affiliations

1 Unitat d'Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain

2 CNRS and University Toulouse III Paul Sabatier, Toulouse, France

3 Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

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BMC Evolutionary Biology 2010, 10:84  doi:10.1186/1471-2148-10-84

Published: 27 March 2010

Additional files

Additional file 1:

Population allele frequencies (second row for each SNP) and heterozygosities (third row and in italics) of the 5 SNPs from the F12 genomic region. The first row for each SNP shows number of individuals typed. Polymorphisms are listed in the same order they are located on the chromosome towards the telomere. The featured frequencies correspond to the allele in bold.

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Additional file 2:

Population allele frequencies of the 3 microsatellite loci from the F12 genomic region. Population allele frequencies of the 3 microsatellite loci from the F12 genomic region.

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Additional file 3:

Variation statistics of the 3 novel microsatellite loci from the broader F12 genomic region. Total heterozygosity (H) refers to the heterozygosity of the pooled sample.

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Additional file 4:

Haplotype frequencies per geographic area (South Europe, North Africa, Ivory Coast) from the F7 and the F12 genomic regions. Sheet 'F7': Haplotype frequencies per geographic area from the F7 genomic region. Microsatellite loci are separated by hyphens while SNPs and the 10 bp insertion/deletion polymorphism are not separated from each other. Numbers in microsatellite loci correspond to the repeat number. SNP and INDEL alleles are annotated by numbers '1' and '2'. The 14 polymorphisms are listed in the same order they appear on the chromosome (here seen in yellow background). Sheet 'F12': Haplotype frequencies per geographic area from the F12 genomic region. Microsatellite loci are separated by hyphens while SNPs are not separated from each other. Numbers in microsatellite loci correspond to repeat number, while SNP alleles are annotated by numbers '1' and '2'. The 8 polymorphisms are listed in the same order they appear on the chromosome (here seen in yellow background).

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Additional file 5:

Pairwise number of shared haplotypes from the F7 and F12 genomic regions. Sheets 'F7 all markers' & 'F7 only SNPs': Pairwise number of shared haplotypes from the F7 genomic region. In sheet 'F7 all markers' estimations were based on SNPs and microsatellites, while in sheet 'F7 only SNPs' estimations were based on SNPs only. Numbers in brackets correspond to the number of distinct haplotypes found in each population. Sheets 'F12 all markers' & 'F12 only SNPs': Pairwise number of shared haplotypes from the F12 genomic region. In sheet 'F12 all markers' estimations were based on SNPs and microsatellites, while in sheet 'F12 only SNPs' estimations were based on SNPs only. Numbers in brackets correspond to the number of distinct haplotypes found in each population.

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Additional file 6:

Nm estimates per pair of Old World populations based on data from both the F7 and F12 genomic regions. Nm estimates per pair of Old World populations based on data from both the F7 and F12 genomic regions.

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