Proposed model for the evolution of the ancient globin cluster. Conserved synteny of globin-flanking genes in extant cephalochordate (amphioxus) and urochordate (C. intestinalis) species together with the MC (green) and LA (violet) globin loci in man and fish. The fusion of three chordate linkage groups (CLG) to form the homolog of the α-containing human chromosome 16 is based on the reported chromosomal rearrangements of the ancestral chordate genome .
Wetten et al. BMC Evolutionary Biology 2010 10:315 doi:10.1186/1471-2148-10-315