Additional file 2.

Deficient activation of Rac1 results in alteration of the shape of large islets. (A,B) Paraffin sections from adult mice stained with H&E. Wild-type islets (A) show a round or oval shape, whereas transgenic islets exhibit a more irregular shape. (C) Quantification of the shape of the 10% largest islets shows a statistical difference between the wild-type and the transgene. The circularity ratio (4πA/p2) was compared between the wild-type and the transgenic islets (n = 3). Error bars represent standard deviation from the mean (± s.d.) and significant values are indicated as *p < 0.05 determined by Student's t-test (n = 3) (A = area, p = perimeter). Bars, 100 μm.

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Greiner et al. BMC Developmental Biology 2009 9:2   doi:10.1186/1471-213X-9-2