Constitutively-active LET-60 suppresses the fli-1 Glm phenotype. Genotypes are along the x axis, and percentage of gonad arms displaying the Glm phenotype are along the y-axis. Numbers of gonads scored for each genotype are indicated. Error bars represent the standard error of the proportion, and matching numbers of asterisks indicate that the genotypes are significantly different (t-test and Fisher's Exact analysis; p < 0.001). (A) Loss-of-function and dominant-negative alleles of let-60 Ras displayed the Glm phenotype whereas constitutively-active alleles did not. (B) Two constitutively-active alleles of let-60 Ras suppress the Glm phenotype of fli-1(ky535) and fli-1(tm362)/+.
Lu et al. BMC Developmental Biology 2008 8:54 doi:10.1186/1471-213X-8-54