FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans
1 Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
2 Current address : Stanford University School of Medicine, Departments of Pediatrics and Genetics, 300 Pasteur Drive, Room H310, Stanford, CA 94305-5208, USA
Citation and License
BMC Developmental Biology 2008, 8:54 doi:10.1186/1471-213X-8-54Published: 16 May 2008
In the C. elegans germ line, syncytial germ line nuclei are arranged at the cortex of the germ line as they exit mitosis and enter meiosis, forming a nucleus-free core of germ line cytoplasm called the rachis. Molecular mechanisms of rachis formation and germ line organization are not well understood.
Mutations in the fli-1 gene disrupt rachis organization without affecting meiotic differentiation, a phenotype in C. elegans referred to here as the
FLI-1 controls germ line morphogenesis and rachis organization, a process about which little is known at the molecular level. The LET-60 Ras GTPase might act with FLI-1 to control germ line morphogenesis.