Comparison of NOGO-A expression to proliferative activity. HH25 (E5) chick optic tectum showing Proliferating Cell Nuclear Antigen (PCNA) immunoreactivity. Section in situ hybridization shows diffuse NOGO-A expression (red) at low levels throughout the proliferative, periventricular neuroepithelium (generative zone, GZ). At HH35 (E10), there is low PCNA staining within the periventricular neuroepithelium, now termed ventricular zone (VZ), while NOGO-A expression has increased (arrowheads highlight PCNA negative nuclei, while arrows point out PCNA positivity). Scale bar 200 μm.
Caltharp et al. BMC Developmental Biology 2007 7:32 doi:10.1186/1471-213X-7-32