Searching for CNEs through functional annotation. As well as viewing annotation for individual CNEs, sequences can be searched for enhancer activity in one or more tissue types (in this example the eye) and one or more developmental stages (24-30 and 48-54 hours post fertilization). Parameters can also be changed to include only strong expressers in the selected tissue type. A composite schematic of the expression domains as well as a histogram of the proportion of embryos expressing in each tissue type are shown for all annotations fulfilling the search criteria. Hyperlinks are provided for each CNE to view annotations in more detail. A multi-FASTA sequence file of the CNEs returned in the search is provided to use in downstream analysis such as searches for overrepresented words/conserved transcription factor binding sites etc responsible for regulation to this tissue.
Woolfe et al. BMC Developmental Biology 2007 7:100 doi:10.1186/1471-213X-7-100