Table 1

Changes in gene expression by BMP4, Noggin, and BSA-soaked beads at E9.5-E11.5

Protein

Stage

Gene

Gene expression altered


BMP4

E11.5 (bead in lens)

Tbx5

10/12 (+)

Tbx2

11/13 (+)

Tbx3

3/3 (+)

Vax2

4/4 (-)

E10.5 (bead in mes)

Tbx5

3/8 (+)

Tbx2

1/4 (+)

Tbx3

0/2

Vax2

0/2

E9.5 (bead in mes)

Tbx5

3/3 (+)

Tbx2

2/2 (+)


BSA

E11.5 (bead in lens)

Tbx5

0/5

Tbx2

0/6

Tbx3

0/1

Vax2

0/6

E10.5 (bead in mes)

Tbx5

0/3

Tbx2

0/2

E9.5 (bead in mes)

Tbx5

0/2


Noggin

E10.5 (bead in mes)

Tbx5

6/6 (-)

Tbx2

4/4 (-)

Tbx3

0/2

Vax2

0/3


Mes, mesenchyme; Altered gene expression after culture with bead: + indicates induction; - indicates repression. Bead implantation was into nasal peri-ocular mesenchyme.

Behesti et al. BMC Developmental Biology 2006 6:62   doi:10.1186/1471-213X-6-62

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