Figure 6.

Leading Edge membrane activity requires Integrin function. The dynamic activity of the leading edge of migrating CBs was monitored in living embryos, labeling membrane actin with dMef-GAL4 regulated UAS-moesin-mCherry, while marking the CBs with tup-F4-GFP. In early stage 16, wildtype CBs of segments 6-8 are 20 microns apart, and extend highly dynamic lamelipodial and filopodial processes to contact their contralateral partners (arrows in A). Although zygotic mutants of mys1 generate similar cell processes (arrows in B), most of the leading edge is quiescent (asterisks), and medial migration is slower. Images are taken at 2 minute intervals; the dorsal midline at t = 0 is marked with a dotted line. Scale: 25 microns

Vanderploeg et al. BMC Developmental Biology 2012 12:8   doi:10.1186/1471-213X-12-8
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