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Open Access Highly Accessed Research article

Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells

Amy C Cash and Justen Andrews*

Author Affiliations

Department of Biology, Indiana University, Myers Hall, 915 East Third St., Bloomington, IN 47403, USA

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BMC Developmental Biology 2012, 12:4  doi:10.1186/1471-213X-12-4

Published: 17 January 2012

Additional files

Additional file 1:

Gene expression from microarray experiment comparing germarium to apex of the testis. Table includes FBgn identifier, gene name, M value, female intensity value, male intensity value, p-value, and FDR adjusted p-value for all genes represented on the microarray. Positive M values indicate enrichment in germaria and negative M values indicate enrichment in testis apex.

Format: XLS Size: 2.1MB Download file

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Open Data

Additional file 2:

Over-represented biological process GO terms from significant germarium-biased and apex of the testis-biased genes. GO analysis was performed using the GO Fat feature in DAVID. Table includes GO term, count (number of genes in the list of significant genes with a given term), population hits (number of genes on the microarray with a given term), p-value, and FDR-corrected p-value.

Format: XLS Size: 29KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

Genes enriched in wild-type GSCs and/or daughters cells in both females and males. Table includes FBgn identifier, gene name, final rank order, M value of germarium vs. apex of the testis, female intensity value, male intensity value, adjusted p-value, M value of female GSCs (dpp-expanded and bam-mutant germ cells) vs. Kc cells [9], adjusted p-value, M value of male stem cells and gonialblasts (Os+bgcn- testes) vs. bgcn- testes [14], adjusted p-value.

Format: XLS Size: 104KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

Genes enriched in the germarium but not in female GSCs. Table includes FBgn identifier, gene name, final rank order, M value of germarium vs. apex of the testis, female intensity value, male intensity value, adjusted p-value, M value of female GSCs (dpp-expanded and bam-mutant germ cells) vs. Kc cells [9], adjusted p-value.

Format: XLS Size: 121KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 5:

Genes enriched in the apex of the testis but not in male stem cells and gonialblasts. Table includes FBgn identifier, gene name, final rank order, M value of germarium vs. apex of the testis, female intensity value, male intensity value, adjusted p-value, M value of male stem cells and gonialblasts (Os+bgcn- testes) vs. bgcn- testes [14], adjusted p-value.

Format: XLS Size: 126KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data