Figure 1.

Relationships between zebrafish and mammalian desmosomal cadherins. A and B. Rooted homology trees outlining the predicted relationship between, and relative evolutionary distance of, zebrafish, human and mouse desmocollins (A) and desmogleins (B). C and D. Predicted domain homology of zfDsc (C) and zfDsga (D) against both relative human and mouse amino acid sequences. EC - extracellular domain, EA - extracellular anchor, TM transmembrane domain, CYT - cytoplasmic domain, TD - terminal domain, IA - intracellular anchor, ICS - intracellular catenin binding sequence, LD -, RUD - repeat unit domain. The sequences were form NCBI as follows: mouse Dsc1a (Accession no. CAA66628), Dsc2a (Accession no. AAA79177), Dsc3a (Accession no. NP_031908), human Dsc1a (Accession no. NP_077739), Dsc2a (Accession no. CAA40141), Dsc3a (Accession no. CAA58781); mouse Dsg1 (Accession no. Q61495), Dsg2 (Accession no. AAH34056), Dsg3 (Accession no. AAB65091), Dsg4 (Accession no. NP_853543), Dsg5 (Accession no. AAP31152), Dsg6 (Accession no. AAP31153), human Dsg1 (Accession no. CAA39976), Dsg2 Accession no. CAA81226), Dsg3 (Accession no. P32926), Dsg4 (Accession no. Q6W3BO).