Table 2

Comparison of Plzf-/- and Plzf7t/7t skeletal phenotypes

Structure

Defect

Plzf-/-

Plzf7t/7t


Hindlimb

digit I>II transformation

92%

100%

preaxial digit resembles digit V or digit I absence

40%

20%

Talus>calcaneus transformation

90%

53%

interdigital webbing

60%

20%

anterior C1 to navicular

38%

C1 to cuboid bone

42%

metatarsal fusion

15%

13%

metatarsal bony outgrowths

69%

40%

absent tibia

98%

separation of tibia and fibula

96%

47%

thickened fibula

32%

40%

tibia to fibula transformation

38%

40%

shortened zeugopod/absent fibula

16%

33%

duplication or absence of patella

52%

0%

absence of meniscus

28%

0%

Forelimb

preaxial polydactyly

5%

0%

interdigital webbing

5%

0%

Axial skeletal

14 thoracic vertebrae

100%

0%

extra pair of ribs attached to sternum

73%

malformed xiphoid process

100%

40%

T10 to T11 vertebrae shift

70%

n/a

homeotic transformation of sacral region

80%

53%

Shortening and kinked tail

100%

0%


Ching et al. BMC Developmental Biology 2010 10:33   doi:10.1186/1471-213X-10-33

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