Bioinformatics analysis of p49 sequence. Bioinformatics analysis of the sequence of human p49 protein shows that there are four classic nuclear localizing sequences (NLS's), three of them are in the N-terminal region. NLS1 & NLS2 are bipartite nuclear localization sequences. NLS3 has a pattern-7 motif, and NLS4 has a pattern-4 motif. Blue (residue K or R) indicates positively charged (basic) residues, red (residue D or E) indicates negatively charged (acidic) residues. The sections underlined in green are highly conserved across human, rat, and mouse.
Zhang et al. BMC Cell Biology 2008 9:8 doi:10.1186/1471-2121-9-8