Cheiradone inhibits cell invasion. The effect of cheiradone on BAEC, and HDMEC cell invasion was studied using the chemoinvasion assay. Cells (1.7 × 104) were added to the Matrigel coated upper Boyden chamber and cheiradone (0–7.7 μM) (control) or cheiradone with VEGF (10 ng/ml) was added to the lower chamber. Cell invasion was measured after 24 h and assessed as described above. Values significantly different (p < 0.05) from VEGF alone are shown by *.
Hussain et al. BMC Cell Biology 2008 9:7 doi:10.1186/1471-2121-9-7