Table 7

FOXO and NFκB regulated genes.

Growth Factor/Receptor or Cytokine

Transcription

Proliferation

Apoptosis

References


FOXO Target Genes


ATROGIN-1

[51]


BCL6

+

+

[49, 50, 80]


BTG1

+

[48, 81]


CCNG2

+

[41,46, 47]


DDIT3/CHOP

+

+

+

[36, 82]


KIF1B


KLF6

+

+

[83]


KLHL24


TXNIP

+

[84]


ZBTB1


NFκB Target Genes


AMIGO2

+

[85]


BDNF

+

+

+

[86]


BIRC3/cIAP2

+

[54, 87]


CCL2

+

+

[55, 88]


CCND1

+

[56]


EDN1-site I

+

+

+

[57, 89, 90]


EDN1-site II

+

+

+

[89, 90]


F3-site I


F3-site II

[58]


FST

+

+

[91]


G0S2

+

[92]


GABPB2

[53]


IGFBP5

+

+

+

[93, 94]


IL7R-site II

+

+

+

[59, 95]


IL7R-site I

+

+

+

[95]


MAT2A-site I


MAT2A-site II

[60]


PLAU

+

+

[61, 96]


PTX3

[62]


RGS20


STC2


TNFRSF11B/osteoprotegerin

+

[40]


All PI 3-kinase regulated genes containing upstream binding sites for either FOXO or NFκB are listed. Genes containing a previously reported FOXO or NFκB binding site, and the relevant reference, are in bold. The biological activity of each gene, as it pertains to growth factor/receptor or cytokine, transcription, proliferation, and apoptosis, is indicated along with references for these activities.

Terragni et al. BMC Cell Biology 2008 9:6   doi:10.1186/1471-2121-9-6

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