Table 3

Summary of Gene Ontology (GO) term analysis.

GO ID

GO name

# Genes

% Genes

p-value


Up-regulated Genes


GO:0032502

Developmental process

15

60

0.00002

GO:0048869

Cellular developmental process

12

48

0.00003

GO:0030154

Cell differentiation

12

48

0.00003

GO:0000122

Negative regulation of transcription from RNA polymerase II promoter

4

16

0.00007

GO:0045892

Negative regulation of transcription, DNA-dependent

4

16

0.00033

GO:0006366

Transcription from RNA polymerase II promoter

6

24

0.00064

GO:0006950

Response to stress

7

28

0.00068

GO:0050794

Regulation of cellular process

14

56

0.00087


Down-regulated Genes


GO:0048519

Negative regulation of biological process

13

27

0.000040

GO:0007267

Cell-cell signaling

10

21

0.000040

GO:0007154

Cell communication

23

48

0.000077

GO:0012501

Programmed cell death

10

21

0.000083

GO:0048523

Negative regulation of cellular process

12

25

0.000085

GO:0007165

Signal transduction

21

44

0.000130

GO:0008219

Cell death

10

21

0.000134

GO:0016265

Death

10

21

0.000134

GO:0009887

Organ morphogenesis

7

15

0.000169

GO:0009605

Response to external stimulus

8

17

0.000432

GO:0042221

Response to chemical stimulus

7

15

0.000490

GO:0007166

Cell surface receptor linked signal transduction

12

25

0.000632

GO:0009653

Anatomical structure morphogenesis

10

21

0.000840


All GO terms in the Biological Process category that were significantly enriched [p ≤ 0.001, Fisher's exact test [76]] amongst the genes changing expression after 2 and 4 hours of LY294002 treatment and were represented in at least 15% of the genes containing GO definitions are listed. The GO ID and name are shown along with the number and percentage of genes that are assigned this term.

Terragni et al. BMC Cell Biology 2008 9:6   doi:10.1186/1471-2121-9-6

Open Data