|
Comparison of the effect of PI 3-kinase inhibition on gene expression in U937 and T98G cells. |
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| Fold Change |
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| U937 cells |
T98G cells |
|
|
|
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| Up-regulated genes |
||
|
|
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| BCL6 |
1.3 |
2.8 |
| BTG1 |
3.4 |
4.1 |
| CCNG2 |
6.6 |
3.0 |
| DDIT3/CHOP |
1.3 |
2.2 |
| IRF7 |
7.6 |
4.2 |
| KLF6/COPEB |
5.7 |
1.5 |
|
|
||
| Down-regulated genes |
||
|
|
||
| BAG2 |
3.3 |
4.3 |
| BIRC3/cIAP2 |
1.7 |
8.9 |
| CCL2 |
51 |
11 |
| F3 |
1.8 |
4.8 |
| IL7R |
2.5 |
2.6 |
| PLAU |
3.4 |
2.1 |
|
Proliferating U937 and T98G cells were treated with LY294002 for 4 hours and gene expression was quantitated by RT-PCR. Data are expressed as average fold changes from two independent experiments. Genes in bold were up- or down-regulated in both cell lines. | ||
Terragni et al. BMC Cell Biology 2008 9:6 doi:10.1186/1471-2121-9-6 |
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