Table 1

Gene expression changes after 2 and 4 hours of PI 3-kinase inhibition

Up-Regulated Genes

Down-Regulated Genes


Gene Symbol

Gene Name

Gene Symbol

Gene Name


APOLD1

Apolipoprotein L domain containing 1

AMD1

S-adenosylmethionine decarboxylase 1

Atrogin-1

F-box protein 32/Atrogin-1

AMIGO2

Adhesion molecule with Ig-like domain 2

BCL6

B-cell CLL/lymphoma 6

ATP13A3

ATPase type 13A3

BTG1

B-cell translocation gene 1

BAG2

BCL2-associated athanogene 2

C1orf183

Chromosome 1 open reading frame 183

BDNF

Brain-derived neurotrophic factor

C1orf63

Chromosome 1 open reading frame 63

BIRC3/cIAP2

Baculoviral IAP repeat-containing 3

CCNG2

Cyclin G2

CCL2

Chemokine (C-C motif) ligand 2

CLK1

CDC-like kinase 1

CCND1

Cyclin D1

CTGF

Connective tissue growth factor

CYP1B1

Cytochrome P450 subfamily I polypeptide 1

DDIT3/CHOP

DNA-damage-inducible transcript 3

DCK

Deoxycytidine kinase

EIF1/SUI1

Eukaryotic translation initiation factor 1

DIO2

Deiodinase, iodothyronine, type II

GADD45B

Growth arrest and DNA-damage-inducible β

DKFZP686E2158

Hypothetical protein LOC643155

ID1

Inhibitor of DNA binding 1

DKK1

Dickkopf homolog 1 (Xenopus laevis)

ID2B

Striated muscle contraction regulatory prot.

DSCR1

Down syndrome critical region gene 1

IRF7

Interferon regulatory factor 7

EDN1

Endothelin 1

KIF1B

Kinesin family member 1B

F3

Coagulation factor III

KLF6

Kruppel-like factor 6

FGF2

Fibroblast growth factor 2

KLHL24

Kelch-like 24

FST

Follistatin

LOC85028

PNAS-123

G0S2

Putative lymphocyte G0/G1 switch gene

MIR

Myosin regulatory light chain interacting prot.

GABPB2

GA binding protein transcription factor, β2

MT1E

Metallothionein 1E

GBP1

Guanylate binding protein 1

PCMTD1

Protein-L-isoaspartate O-methyltransferase

GBP3

Guanylate binding protein 3

PHLDA1

Pleckstrin homology-like domain family A

GLIPR1

Glioma pathogenesis-related protein

PNPLA8

Patatin-like phospholipase domain 8

GPR19

G protein-coupled receptor 19

RNU2

RNA, U2 small nuclear

GRIK1

Glutamate receptor, ionotropic, kainate 1

SAT

Spermine N1-acetyltransferase

GRO3

GRO3 oncogene

STK31

Serine/threonine kinase 31

IGFBP5

Insulin-like growth factor binding protein 5

TAF9

TAF9 RNA polymerase II

IL7R

Interleukin 7 receptor

TIEG

TGFβ inducible early growth response

ISG20L1

Interferon stimulated exonuclease

TXNIP

Thioredoxin interacting protein

LOC57090

HRPAP20 short form

ZBTB1

Zinc finger and BTB domain containing 1

LTV1

LTV1 homolog (S. cerevisiae)

cDNA DKFZp564C2063

MAT2A

Methionine adenosyltransferase II, alpha

MMP3

Matrix metalloproteinase 3

NAV3

Neuron navigator 3

NCOA7

Nuclear receptor coactivator 7

NOLA1

Nucleolar protein family A, member 1

NTF3

Neurotrophin 3

NXT1

NUTF-like export factor1

PAK1IP1

PAK1 interacting protein 1

PLAU

Plasminogen activator, urokinase

PPIF

Peptidylprolyl isomerase F (cyclophilin F)

PTRH2

Peptidyl-tRNA hydrolase 2

PTX3

Pentaxin-related gene

RGS20

Regulator of G-protein signalling 20

SC4MOL

Sterol-C4-methyl oxidase-like

SFRS3

Splicing factor, arginine/serine-rich 3

SGNE1

Secretory granule, neuroendocrine protein 1

SNK

Serum-inducible kinase

STC2

Stanniocalcin 2

TNFRSF11B

Tumor necrosis factor receptor 11b (OPG)

TRIM16

Tripartite motif-containing 16

TSLP

Thymic stromal lymphopoietin

cDNA FLJ11812 fis, clone HEMBA1006364


Terragni et al. BMC Cell Biology 2008 9:6   doi:10.1186/1471-2121-9-6

Open Data