Table 1

Gene expression changes after 2 and 4 hours of PI 3-kinase inhibition

Up-Regulated Genes
Down-Regulated Genes

Gene Symbol
Gene Name
Gene Symbol
Gene Name

APOLD1
Apolipoprotein L domain containing 1
AMD1
S-adenosylmethionine decarboxylase 1
Atrogin-1
F-box protein 32/Atrogin-1
AMIGO2
Adhesion molecule with Ig-like domain 2
BCL6
B-cell CLL/lymphoma 6
ATP13A3
ATPase type 13A3
BTG1
B-cell translocation gene 1
BAG2
BCL2-associated athanogene 2
C1orf183
Chromosome 1 open reading frame 183
BDNF
Brain-derived neurotrophic factor
C1orf63
Chromosome 1 open reading frame 63
BIRC3/cIAP2
Baculoviral IAP repeat-containing 3
CCNG2
Cyclin G2
CCL2
Chemokine (C-C motif) ligand 2
CLK1
CDC-like kinase 1
CCND1
Cyclin D1
CTGF
Connective tissue growth factor
CYP1B1
Cytochrome P450 subfamily I polypeptide 1
DDIT3/CHOP
DNA-damage-inducible transcript 3
DCK
Deoxycytidine kinase
EIF1/SUI1
Eukaryotic translation initiation factor 1
DIO2
Deiodinase, iodothyronine, type II
GADD45B
Growth arrest and DNA-damage-inducible β
DKFZP686E2158
Hypothetical protein LOC643155
ID1
Inhibitor of DNA binding 1
DKK1
Dickkopf homolog 1 (Xenopus laevis)
ID2B
Striated muscle contraction regulatory prot.
DSCR1
Down syndrome critical region gene 1
IRF7
Interferon regulatory factor 7
EDN1
Endothelin 1
KIF1B
Kinesin family member 1B
F3
Coagulation factor III
KLF6
Kruppel-like factor 6
FGF2
Fibroblast growth factor 2
KLHL24
Kelch-like 24
FST
Follistatin
LOC85028
PNAS-123
G0S2
Putative lymphocyte G0/G1 switch gene
MIR
Myosin regulatory light chain interacting prot.
GABPB2
GA binding protein transcription factor, β2
MT1E
Metallothionein 1E
GBP1
Guanylate binding protein 1
PCMTD1
Protein-L-isoaspartate O-methyltransferase
GBP3
Guanylate binding protein 3
PHLDA1
Pleckstrin homology-like domain family A
GLIPR1
Glioma pathogenesis-related protein
PNPLA8
Patatin-like phospholipase domain 8
GPR19
G protein-coupled receptor 19
RNU2
RNA, U2 small nuclear
GRIK1
Glutamate receptor, ionotropic, kainate 1
SAT
Spermine N1-acetyltransferase
GRO3
GRO3 oncogene
STK31
Serine/threonine kinase 31
IGFBP5
Insulin-like growth factor binding protein 5
TAF9
TAF9 RNA polymerase II
IL7R
Interleukin 7 receptor
TIEG
TGFβ inducible early growth response
ISG20L1
Interferon stimulated exonuclease
TXNIP
Thioredoxin interacting protein
LOC57090
HRPAP20 short form
ZBTB1
Zinc finger and BTB domain containing 1
LTV1
LTV1 homolog (S. cerevisiae)

cDNA DKFZp564C2063
MAT2A
Methionine adenosyltransferase II, alpha


MMP3
Matrix metalloproteinase 3


NAV3
Neuron navigator 3


NCOA7
Nuclear receptor coactivator 7


NOLA1
Nucleolar protein family A, member 1


NTF3
Neurotrophin 3


NXT1
NUTF-like export factor1


PAK1IP1
PAK1 interacting protein 1


PLAU
Plasminogen activator, urokinase


PPIF
Peptidylprolyl isomerase F (cyclophilin F)


PTRH2
Peptidyl-tRNA hydrolase 2


PTX3
Pentaxin-related gene


RGS20
Regulator of G-protein signalling 20


SC4MOL
Sterol-C4-methyl oxidase-like


SFRS3
Splicing factor, arginine/serine-rich 3


SGNE1
Secretory granule, neuroendocrine protein 1


SNK
Serum-inducible kinase


STC2
Stanniocalcin 2


TNFRSF11B
Tumor necrosis factor receptor 11b (OPG)


TRIM16
Tripartite motif-containing 16


TSLP
Thymic stromal lymphopoietin



cDNA FLJ11812 fis, clone HEMBA1006364

Terragni et al. BMC Cell Biology 2008 9:6   doi:10.1186/1471-2121-9-6