Table 1 |
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Gene expression changes after 2 and 4 hours of PI 3-kinase inhibition |
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Up-Regulated Genes |
Down-Regulated Genes |
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Gene Symbol |
Gene Name |
Gene Symbol |
Gene Name |
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APOLD1 |
Apolipoprotein L domain containing 1 |
AMD1 |
S-adenosylmethionine decarboxylase 1 |
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Atrogin-1 |
F-box protein 32/Atrogin-1 |
AMIGO2 |
Adhesion molecule with Ig-like domain 2 |
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BCL6 |
B-cell CLL/lymphoma 6 |
ATP13A3 |
ATPase type 13A3 |
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BTG1 |
B-cell translocation gene 1 |
BAG2 |
BCL2-associated athanogene 2 |
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C1orf183 |
Chromosome 1 open reading frame 183 |
BDNF |
Brain-derived neurotrophic factor |
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C1orf63 |
Chromosome 1 open reading frame 63 |
BIRC3/cIAP2 |
Baculoviral IAP repeat-containing 3 |
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CCNG2 |
Cyclin G2 |
CCL2 |
Chemokine (C-C motif) ligand 2 |
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CLK1 |
CDC-like kinase 1 |
CCND1 |
Cyclin D1 |
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CTGF |
Connective tissue growth factor |
CYP1B1 |
Cytochrome P450 subfamily I polypeptide 1 |
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DDIT3/CHOP |
DNA-damage-inducible transcript 3 |
DCK |
Deoxycytidine kinase |
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EIF1/SUI1 |
Eukaryotic translation initiation factor 1 |
DIO2 |
Deiodinase, iodothyronine, type II |
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GADD45B |
Growth arrest and DNA-damage-inducible β |
DKFZP686E2158 |
Hypothetical protein LOC643155 |
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ID1 |
Inhibitor of DNA binding 1 |
DKK1 |
Dickkopf homolog 1 (Xenopus laevis) |
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ID2B |
Striated muscle contraction regulatory prot. |
DSCR1 |
Down syndrome critical region gene 1 |
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IRF7 |
Interferon regulatory factor 7 |
EDN1 |
Endothelin 1 |
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KIF1B |
Kinesin family member 1B |
F3 |
Coagulation factor III |
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KLF6 |
Kruppel-like factor 6 |
FGF2 |
Fibroblast growth factor 2 |
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KLHL24 |
Kelch-like 24 |
FST |
Follistatin |
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LOC85028 |
PNAS-123 |
G0S2 |
Putative lymphocyte G0/G1 switch gene |
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MIR |
Myosin regulatory light chain interacting prot. |
GABPB2 |
GA binding protein transcription factor, β2 |
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MT1E |
Metallothionein 1E |
GBP1 |
Guanylate binding protein 1 |
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PCMTD1 |
Protein-L-isoaspartate O-methyltransferase |
GBP3 |
Guanylate binding protein 3 |
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PHLDA1 |
Pleckstrin homology-like domain family A |
GLIPR1 |
Glioma pathogenesis-related protein |
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PNPLA8 |
Patatin-like phospholipase domain 8 |
GPR19 |
G protein-coupled receptor 19 |
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RNU2 |
RNA, U2 small nuclear |
GRIK1 |
Glutamate receptor, ionotropic, kainate 1 |
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SAT |
Spermine N1-acetyltransferase |
GRO3 |
GRO3 oncogene |
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STK31 |
Serine/threonine kinase 31 |
IGFBP5 |
Insulin-like growth factor binding protein 5 |
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TAF9 |
TAF9 RNA polymerase II |
IL7R |
Interleukin 7 receptor |
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TIEG |
TGFβ inducible early growth response |
ISG20L1 |
Interferon stimulated exonuclease |
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TXNIP |
Thioredoxin interacting protein |
LOC57090 |
HRPAP20 short form |
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ZBTB1 |
Zinc finger and BTB domain containing 1 |
LTV1 |
LTV1 homolog (S. cerevisiae) |
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cDNA DKFZp564C2063 |
MAT2A |
Methionine adenosyltransferase II, alpha |
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MMP3 |
Matrix metalloproteinase 3 |
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NAV3 |
Neuron navigator 3 |
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NCOA7 |
Nuclear receptor coactivator 7 |
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NOLA1 |
Nucleolar protein family A, member 1 |
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NTF3 |
Neurotrophin 3 |
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NXT1 |
NUTF-like export factor1 |
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PAK1IP1 |
PAK1 interacting protein 1 |
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PLAU |
Plasminogen activator, urokinase |
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PPIF |
Peptidylprolyl isomerase F (cyclophilin F) |
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PTRH2 |
Peptidyl-tRNA hydrolase 2 |
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PTX3 |
Pentaxin-related gene |
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RGS20 |
Regulator of G-protein signalling 20 |
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SC4MOL |
Sterol-C4-methyl oxidase-like |
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SFRS3 |
Splicing factor, arginine/serine-rich 3 |
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SGNE1 |
Secretory granule, neuroendocrine protein 1 |
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SNK |
Serum-inducible kinase |
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STC2 |
Stanniocalcin 2 |
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TNFRSF11B |
Tumor necrosis factor receptor 11b (OPG) |
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TRIM16 |
Tripartite motif-containing 16 |
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TSLP |
Thymic stromal lymphopoietin |
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cDNA FLJ11812 fis, clone HEMBA1006364 |
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Terragni et al. BMC Cell Biology 2008 9:6 doi:10.1186/1471-2121-9-6 |
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