Table 2

Inhibition of tubular transformation by small molecules.

CACO2

Mouse

Note

Inhibitors

μg/ml (ppm)

Tubular T. (Morphology And count)

mg/kg/day (ppm/day)

SBC (%) Reduction

Mode of action (References)


Sphingosine-1-phosphate

200

no inhibition

1

no change

compete for ceramide mediated apoptosis [12]

Q-VD-OPh

200

no inhibition

2

no change

compete for caspase mediated apoptosis [9, 13]

Pyridinyl Imidazole

10

> 90% inhibition

0.01

30

bind to a P38 MAPK Kd = 38 nm [18]


Wu et al. BMC Cell Biology 2008 9:26   doi:10.1186/1471-2121-9-26

Open Data