Comparison of tubular transformation with apoptotic bodies.A. No appearance of DNA ladder (left panel) in CACO2 cells during a successful tubular transformation induced by dehydration. DNA ladder did appear (right panel) in CACO2 cells during a failed tubular transformation B. Measurement of caspase-3/7 activity during dehydration induced tubular transformation in CACO2 cells. C. Inhibition of tubular transformation by small molecules in vivo. Blood samples are counted from a single dose sc at 24 hr.
Wu et al. BMC Cell Biology 2008 9:26 doi:10.1186/1471-2121-9-26