Open Access Research article

Full Length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons

Hans-Georg König1, Markus Rehm1, Daniel Gudorf2, Stan Krajewski3, Atan Gross4, Manus W Ward1 and Jochen HM Prehn1*

Author Affiliations

1 Department of Physiology and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland

2 Interdisciplinary Center for Clinical Research, University Münster Clinics, D-48149 Münster, Germany

3 The Burnham Institute, Program on Apoptosis and Cell Death, La Jolla, CA 92037, USA

4 Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

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BMC Cell Biology 2007, 8:7  doi:10.1186/1471-2121-8-7

Published: 27 February 2007

Additional files

Additional File 1:

Long exposures for Figure 1A, B and 1C. The abundance of the FL-Bid in relation to the cleaved-Bid fragments is depicted on one blot. In contrast to STS and TNF-α treated HeLa cells no such band is visible after treatment of the hippocampal neurons with NMDA.

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