Calcineurin-inhibitor cypermethrin blocks carbachol-induced dispersion. Isolated RPE cells were first treated with 10 μM forskolin for 45' to induce aggregation. Following aggregation, carbachol (100 nM) was tested along with the calcineurin inhibitor cypermethrin (100 pM). Cypermethrin-treated cells experienced 100% inhibition in dispersion.
Johnson and García BMC Cell Biology 2007 8:53 doi:10.1186/1471-2121-8-53