The Atf4 KO mice show pancreatic hypotrophy. As early as P4, Atf4 KO mice show fewer and smaller acinar cells in the exocrine pancreas (A, P4 wild-type; B, P4 Atf4 KO, 400x). The arrows point to tubular structures. By three months of age, the majority of the exocrine pancreas is replaced by adipocytes (C, Atf4 KO).
Iida et al. BMC Cell Biology 2007 8:38 doi:10.1186/1471-2121-8-38