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Open Access Research article

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice

Kaori Iida1, Yulin Li2, Barbara C McGrath2, Ami Frank3 and Douglas R Cavener2*

Author Affiliations

1 Department of History of Science and Technology, Johns Hopkins University, Baltimore, MD 21218, USA

2 Department of Biology, Penn State University, University Park, PA 16802, USA

3 Bacterial Diseases of Livestock, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA

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BMC Cell Biology 2007, 8:38  doi:10.1186/1471-2121-8-38

Published: 29 August 2007

Additional files

Additional file 1:

Summary of microarray data for genes that show increased expression in mutant pancreata. A table listing genes that were shown to be up-regulated in the pancreata of Perk-/- mice compared to wild-type at P16, P19 and P32.

Format: PDF Size: 85KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Summary of microarray data for genes that show decreased expression levels. A table listing genes that were shown to be down-regulated in the pancreata of Perk-/- mice compared to wild-type at P16, P19 and P32.

Format: PDF Size: 109KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Results of microarray analyses for major ER-resident and ER-stress related genes. A table that compares known ER-resident or ER-stress related genes for Perk-/- and wild-type mice at P16. P19 and P32.

Format: PDF Size: 29KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Results of microarray analyses for major apoptosis-related genes. A table that compares known apoptosis-related genes for Perk-/- and wild-type mice at P16. P19 and P32.

Format: PDF Size: 37KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data