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Open Access Highly Accessed Research article

Establishment and mitotic stability of an extra-chromosomal mammalian replicon

Isa M Stehle1, Jan Postberg1, Sina Rupprecht1, Thomas Cremer2, Dean A Jackson3* and Hans J Lipps1*

Author Affiliations

1 Institute of Cell Biology, University Witten/Herdecke, Stockumer Str. 10, 58453 Witten, Germany

2 Department of Biology II, Anthropology and Human Genetics, Ludwig Maximilians University Munich, Großhaderner Straße 2, 82152 Martinsried, Germany

3 Faculty of Life Sciences, University of Manchester, Manchester, Sackville Street, Manchester, M60 1QD, UK

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BMC Cell Biology 2007, 8:33  doi:10.1186/1471-2121-8-33

Published: 6 August 2007

Additional files

Additional file 1:

Table S-1. Co-localization of pEPI episomes with the interchromatin compartment.

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Additional file 2:

Figure S-1. Selected single optical sections corresponding to maximum intensity projections displayed in Figure 3C,D.

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Additional file 3:

Figure S-2. Average number of episomes bound to each of the 20 chromosomes of CHO C400 cells.

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Additional file 4:

Table S-2. FISH analyses of metaphase spreads of pEPI transfected CHO C400 cells.

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Additional file 5:

Table S-3. Distribution of pEPI molecules to daughter nuclei after mitosis.

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