Dishevelled stabilises microtubules through inhibition of Gsk3β and a second signalling pathway. A) Diagram shows Dvl binding to the MT network and inhibiting a pool of Gsk3β resulting in changes in the phosphorylation of MAP1B and increased microtubule stability. B) Neurons expressing Dvl contain stable MTs after Nocodazole treatment. Expression of Gsk3β partially blocks the ability of Dvl to stabilize MTs. C) Quantification shows that Dvl alone induces MT stability when compared to control EGFP-expressing neurons. Neurons expressing Gsk3β alone does not induce Mt stability while neurons expressing both Gsk3β and Dvl exhibit decreased MT stability when compared to Dvl-expressing neurons. Scale bar: 15 μm. Three asterisks, P < 0.001; For asterisks, P < 0.0001.
Ciani and Salinas BMC Cell Biology 2007 8:27 doi:10.1186/1471-2121-8-27