(a) Representative normal murine skin shows the presence of an orderly collagen in the dermis and hair follicles, with associated sebacecous glands. (b) After a full-thickness wound has healed, the skin forms a stratified epithelium over a fibroblast-rich dermis, lacking the epithelial appendages seen in 1a. (c) PCR analysis of normal murine skin shows the presence of Wnt-4, -5a, -7a, -10b and -11. (d) Real time PCR analysis of wounds examined at several time points shows Wnt-4 expression peaking at day 7 after wounding, whereas Wnt 5a and -11 expression levels peak 21 days after wounding, or 1 week after epithelialization has completed.
Fathke et al. BMC Cell Biology 2006 7:4 doi:10.1186/1471-2121-7-4