Effect of β-estradiol on MMP-2 gene expression. MMP-2 mRNA (pg/μg total RNA) was quantified by RT-PCR analysis after 24 hours. White bars: fibroblasts without estrogen stimulation; black bars: fibroblasts after 24 hours of stimulation with 0.25 ng/ml β-estradiol. A: fibroblasts derived from female patients; B: fibroblasts derived from male patients; Data are presented as means +/- standard deviation;* p < 0.05 vs. CFs.
Jansen et al. BMC Cell Biology 2006 7:36 doi:10.1186/1471-2121-7-36