CtBP gene structure and sequence comparison. (a) Genomic structure of the 5' end of human CTBP1 and CTBP2 genes. Published cDNA sequences were compared to human genome sequences using BLAST analysis. Solid lines show splicing of the major CTBP1 and CTBP2 transcripts, and dotted lines indicate the alternate splicing to generate CtBP1-S and RIBEYE. (b) ClustalW alignment of CtBP sequences from multiple higher organisms. Putative nuclear localisation signals are highlighted in bold type. The residues deleted in the Δ4–14 constructs are marked. Zebrafish have two ctbp2/ribeye loci .
Bergman et al. BMC Cell Biology 2006 7:35 doi:10.1186/1471-2121-7-35