P-MCAK is highly similar to H-MCAK. An alignment of P-MCAK, H-MCAK and X-MCAK proteins is shown. All 3 proteins share significant identity in the N-terminal centromere targeting domain (blue brackets) and the centrally located catalytic core (red brackets). The major Aurora B phosphorylation sites that regulate centromere-targeting and microtubule depolymerization activity are also conserved and are indicated in green.
Stout et al. BMC Cell Biology 2006 7:26 doi:10.1186/1471-2121-7-26