|
Effect of the inhibitors of tryptase or elastase on tryptase or elastase induced release of IL-8 from A549 cells |
|
| Compound (μg/ml) |
IL-8 released (pg/ml) |
|
|
|
| Medium alone |
24.6 ± 1.5 |
| Tryptase 2.0 |
105.2 ± 5.3* |
| Elastase 0.3 |
108.4 ± 13.2* |
| Benzamidine 30 |
37.6 ± 4.4 |
| Leupeptine 30 |
27.4 ± 5.6 |
| MSACK 30 |
22.1 ± 4.3 |
| Tryptase 2.0 + Benzamidine 30 |
66.9 ± 4.8† |
| Tryptase 2.0 + Leupeptin 30 |
100 ± 1.7 |
| Elastase 0.3 + MSACK 30 |
26.9 ± 3.6† |
|
Data shown are mean ± SE for five to six separate experiments. Stimulus, inhibitor, or stimulus with inhibitor was incubated with cells for 16 h. * P < 0.05 compared with the response to medium alone; †P < 0.05 compared with the corresponding stimulus alone. | |
Wang et al. BMC Cell Biology 2006 7:22 doi:10.1186/1471-2121-7-22 |
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