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Open Access Commentary

A new standard nomenclature for proteins related to Apx and Shroom

Olivier Hagens1, Andrea Ballabio2, Vera Kalscheuer1, Jean-Pierre Kraehenbuhl3, M Vittoria Schiaffino4, Peter Smith5, Olivier Staub6, Jeff Hildebrand7 and John B Wallingford8*

Author Affiliations

1 Dept. of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany

2 Telethon Institute of Genetics and Medicine, Naples, Italy

3 Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland

4 Dept. of Biotechnology, San Raffaele Scientific Institute, Milan, Italy

5 Dept. of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA

6 Dept. of Pharmacology & Toxicology, University of Lausanne, Lausanne, Switzerland

7 Dept. of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA

8 Dept. of Molecular Cell and Developmental Biology & Institute for Cellular and Molecular Biology, University of Texas, Austin, TX, USA

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BMC Cell Biology 2006, 7:18  doi:10.1186/1471-2121-7-18

Published: 14 April 2006

Abstract

Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. At present these proteins are named Shroom, APX, APXL, and KIAA1202. In light of the growing interest in this family of proteins, we propose here a new standard nomenclature.