Thalidomide attenuates tube formation in ECs. ECs were seeded on collagen coated 12 well plates with 60% cell density, induced with SNP (500 μmol) and incubated at 37°C/5% CO2 for 24 hours. A reduction inthe number of NO mediated tubes has been observed by 43% and 40% in 50 and 75 μg/ml thalidomide treated cells respectively.
Tamilarasan et al. BMC Cell Biology 2006 7:17 doi:10.1186/1471-2121-7-17