Cytokinesis inhibitors do not block the G1 to S phase progression of binucleate HDF cells. Serum-starved G0 cells were fused and released into medium containing BrdU and (A) no drug, (B) 25 μM blebbistatin, (C) 5 μM AKI-1, or (D) 5 μM cytochalasin. Some cells remain unfused after the fusion treatment, and were used as mononucleate controls. Time points were taken to assay for S phase entry.
Wong and Stearns BMC Cell Biology 2005 6:6 doi:10.1186/1471-2121-6-6