Table 1

Kinetic (reaction events given in Fig. 2) and transport (monomer and dimer diffusion) parameters used in hybrid null-event MC model (factors of 1/2 and 1/4 discussed in the Methods section have to be considered).

Equilibrium constants


K1

13.3 (molecule/site)-1

In the range to be consistent with ~18% of the monomer EGFR as dimers in the absence of EGF [9, 53–56]

K2

4.0 × 103 (molecule/site)-1

Calculated based on equilibrium relations given in [14]

K3

1.2 × 106 (molecule/site)-1

Calculated based on equilibrium relations given in [14]

K4

4 × 108 M-1

In the range suggested by [1, 4, 58–60]

K5, K6

1.2 × 1011 M-1

In the range suggested by [9, 53–56]


Kinetic parameters


k1b, k2b

0.17 sec-1

[61]

k3b

1.7 × 10-3 sec-1

[61]

k4b, k5b

2.9 × 10-3 sec-1

[34]

k6b

5.8 × 10-3 sec-1

[34]


Transport parameters


Dmonomer

2 × 10-14–2 × 10-15 m2sec-1

[49, 50]


Mayawala et al. BMC Cell Biology 2005 6:41   doi:10.1186/1471-2121-6-41

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