|
Kinetic (reaction events given in Fig. 2) and transport (monomer and dimer diffusion) parameters used in hybrid null-event MC model (factors of 1/2 and 1/4 discussed in the Methods section have to be considered). |
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| Equilibrium constants |
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| K1 |
13.3 (molecule/site)-1 |
In the range to be consistent with ~18% of the monomer EGFR as dimers in the absence of EGF [9, 53–56] |
| K2 |
4.0 × 103 (molecule/site)-1 |
Calculated based on equilibrium relations given in [14] |
| K3 |
1.2 × 106 (molecule/site)-1 |
Calculated based on equilibrium relations given in [14] |
| K4 |
4 × 108 M-1 |
In the range suggested by [1, 4, 58–60] |
| K5, K6 |
1.2 × 1011 M-1 |
In the range suggested by [9, 53–56] |
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| Kinetic parameters |
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| k1b, k2b |
0.17 sec-1 |
[61] |
| k3b |
1.7 × 10-3 sec-1 |
[61] |
| k4b, k5b |
2.9 × 10-3 sec-1 |
[34] |
| k6b |
5.8 × 10-3 sec-1 |
[34] |
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| Transport parameters |
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| Dmonomer |
2 × 10-14–2 × 10-15 m2sec-1 |
[49, 50] |
Mayawala et al. BMC Cell Biology 2005 6:41 doi:10.1186/1471-2121-6-41 |
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