Schematic representation of human LPP and Scrib proteins. (A) Schematic representation of the human LPP protein. Human LPP contains a proline-rich pre-LIM region followed by three tandem LIM domains. In its pre-LIM region, LPP harbors one nuclear export signal, two VASP binding sites and one α-actinin binding site. Furthermore, LPP has two regions in common with its family member TRIP6 and one region with its family members zyxin, TRIP6 and LIMD1. At its carboxy-terminus, LPP has a binding site for Scrib. (B) Schematic representation of the human Scrib protein human Scrib is a 1630 amino acid protein that contains 16 leucine-rich repeats (LRR) followed by 2 domains that are specific for the LAP family of proteins (LAP-specific domain (LAPSD) a and b), and 4 PDZ domains. The corresponding position of the mouse Scrib prey clone that was isolated in a yeast-two hybrid screen using LPP as bait is indicated. The amino acid sequence of the PDZ domains of mouse Scrib was compared to that of human Scrib, and percentage identity is indicated for each PDZ domain.
Petit et al. BMC Cell Biology 2005 6:1 doi:10.1186/1471-2121-6-1