Table 2 |
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|
Effect of Bax genotype on properties of myofibers in vivo. |
||||
|
Property |
Muscle |
Bax-positive ave ± SE (n) |
Bax-null ave ± SE (n) |
Significance* |
|
Cross-sectional area (μm2) of fast‡ myofibers |
Soleus |
1045 ± 17.0 (451) |
785 ± 11.9 (500) |
P < 0.0001 |
|
Diaphragm |
873 ± 7.7 (1364) |
717 ± 6.9 (1570) |
P < 0.0001 |
|
|
Cross-sectional area (μm2) of slow‡ myofibers |
Soleus |
1399 ± 33.7 (193) |
1096 ± 16.6 (270) |
P < 0.0001 |
|
Diaphragm |
640 ± 15.0 (136) |
547 ± 12.8 (150) |
P < 0.0001 |
|
|
Percentage of fast myofibers |
Soleus |
70.2 ± 1.8 (3) |
70.8 ± 0.1 (3) |
P > 0.7 |
|
Diaphragm |
90.7 ± 0.7 (5) |
91.2 ± 0.8 (5) |
P > 0.7 |
|
|
Cross-sectional area (mm2) of whole muscle |
Soleus |
1.54 ± 0.12 (4) |
1.18 ± 0.06 (5) |
P = 0.024 |
|
Total number of myofibers |
Soleus |
1081 ± 36 (4) |
1102 ± 17 (5) |
P > 0.5 |
|
|
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|
‡Fast and slow myofibers were identified by ATPase staining as described in Methods. *Comparison of Bax-positive to Bax-null with unpaired, two-tailed, t-test. |
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|
Nowak et al. BMC Cell Biology 2004 5:1 doi:10.1186/1471-2121-5-1 |
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