Interferons regulation of rat hepatic stellate cell proliferation. Sub-cultured hepatic stellate cells were incubated with 500 U/ml of interferons for the days indicated. Cell proliferation was performed by WST-1 cell proliferation and BrdU incorporation assays. Panel A exhibits the effect of IFN-α on cell proliferation. Panel B indicates the effect of IFN-β on cell proliferation. Panel C displays the effect of IFN-γ on cell proliferation. Panel D exhibits the IFNs effect on BrdU incorporation in rat HSCs. The data represent mean ± SEM. HI represents heat-inactivation. * indicates p < 0.05 and ** indicates p < 0.01.
Shen et al. BMC Cell Biology 2002 3:9 doi:10.1186/1471-2121-3-9