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Open Access Highly Accessed Research article

Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest

Christopher J Armit1*, Shirley O'Dea2, Alan R Clarke3 and David J Harrison1

Author Affiliations

1 CRC Laboratories, Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK

2 Present address; Mucosal Immunology Laboratory, Biology Department, N.U.I. Maynooth, Co.Kildare, Republic of Ireland

3 Present address; Cardiff University, School of Biosciences, Cardiff CF10 3US, UK

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BMC Cell Biology 2002, 3:27  doi:10.1186/1471-2121-3-27

Published: 21 November 2002

Additional files

Additional file 1:

Movie demonstrating mitosis abnormalities in p53-/- Clara cells Clara cells isolated and cultured from gene-targeted mice germline deficient in p53 display cell division abnormalities whereby nuclei fail to segregate mitotically during the final stage of the cell cycle. Spontaneous binucleation and the formation of multiple spindle poles in these cultures highlight functions of wild type p53 in the formation of bipolar spindles. Movie is stored in a Flash (.swf) format, and can be accessed with Flash, QuickTime, Netscape, and Internet Explorer. The additional file can alternatively be accessed via the following website: http://www.ed.ac.uk/pathology/Research/Research_Interests/Chris_armit/clara.htm webcite.

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