Table 1

Mutations affecting the GTP/GDP cycle of Rab27a

Rab27a mutation

expected biochemical properties

expected effect


T23N

preferential binding of GDP

dominant-negative

Q78L

reduced GTPase activity

constitutively-active

N133I

low affinity for GDP/GTP

dominant-negative


Ramalho et al. BMC Cell Biology 2002 3:26   doi:10.1186/1471-2121-3-26

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