Table 1

Modulation of P-gp expression by agents that induce astroglial reactivity.

Treatment

Concentration

Effect


dBcAMP

0,5 mM

- 3.1 ± 8

IL-1β

50 ng/ml

+10.5 ± 11

Lesion

/

- 12.1 ± 8

LPS

1 μg/ml

+ 2.3 ± 8

NGF

10 ng/ml

- 21.7 ± 22

RA

10-7 M

- 28.6 ± 20.2

rhIFN-β

600 U/ml

-20 ± 11

rhIFNγ

rhTGFα

300 U/ml

50 ng/ml

+50 ± 30

-9 ± 5

TNFα

100 ng/ml

+ 7.6 ± 9.1

rhCT-1

10 ng/ml

+ 69.6 ± 24**

rhLIF

30 ng/ml

+ 54.3 ± 12**

rmIL-6

40 ng/ml

+68.8 ± 10***

RmIL-6

50 ng/ml

+220.28 ± 22***

+

rhsIL-6R

500 ng/ml

rrCNTF

250 ng/ml

+ 75.7 ± 30*


*: ANOVA significant at 95%, t-test p < 0.05; **: ANOVA significant at 95%, t-test p < 0.01; ***: ANOVA significant at 95%, t-test p < 0.001.

Monville et al. BMC Cell Biology 2002 3:20   doi:10.1186/1471-2121-3-20

Open Data