Effect on FAP-α overexpression and cellular behaviour. (A) Increased invasion was observed in both MCF7 and MDA-MB-231 cells Overexpressing FAP-α (n = 8). (B) Adhesion to basement membrane showed that MCF7exp cells exhibited lower adhesion but that MDA-MB-231exp cells were more adhesive (n = 8). (C, top) ECIS experiments showed that MCF7exp cell showed reduced attachment after 2 hour, whereas MDA-MB-231exp attachment was increased (C, bottom). (D) In the migration phase, motility of both MCF7exp cells and MDA-MB-231exp cells was dramatically reduced compared to the wild type and control cells (n = 16).
Jia et al. BMC Cell Biology 2014 15:16 doi:10.1186/1471-2121-15-16