H-RN inhibits human umbilical vein endothelial cell (HUVEC) proliferation while scrambled peptide exerts no effect. Following starvation, HUVECs were incubated with vascular endothelial growth factor (VEGF) (100 ng/ml) and various concentrations of H-RN or scrambled peptide for 24 h. Cell proliferation was significantly inhibited by H-RN, especially at 1 mM. Scrambled peptide had no inhibitory activity on HUVECs at various concentrations (*p<0.05, each condition versus VEGF group).
Sun et al. BMC Cell Biology 2013 14:8 doi:10.1186/1471-2121-14-8