CD44+CD117+CSCs with multidrug resistance property in 3D culture. A shows the cellular growth inhibitory rates of anticancer drugs 5FU, CDDP, CBP, and DXT to the CD44+CD117+CSCs and the SKOV-3 cells in 3D culture and the 2D one, respectively. IC50 concentrations of 5FU, CDDP, CBP and DXT were 17.18 μg/mL, 18.6 μg/mL, 20.5 μg/mL, and 72 μg/mL, respectively, in the CD44+CD117+CSCs group. B likewise indicates the inhibitory rates of 5FU, CDDP, CBP, and DXT to CD44+CD117+CSCs and SKOV-3 cells in IC50 concentration, two-folds IC50 concentration and ten-folds IC50 concentration, respectively. * P < 0.05 and #P > 0.05.
Chen et al. BMC Cell Biology 2013 14:7 doi:10.1186/1471-2121-14-7