Amino acid sequence of BORIS showing predicted nuclear localisation signal (green) and nuclear export signal (blue). The unstructured N and C terminal regions  that flank the 11 Zinc-finger domains (black) are coloured red. In the C-terminal region, bold, underlined residues (green) represent a predicted nuclear localisation signal (NLS) (http://www.sbc.su.se/~maccallr/nucpred/cgi-bin/single.cgi webcite). At the end of the C-terminal region, bold, underlined residues (blue) represent a predicted nuclear export signal (NES) (http://www.cbs.dtu.dk/services/NetNES/ webcite). The predicted export signal was identified when using the unstructured C-terminal (red) as input. No other NES were found in the other regions, i.e. the unstructured N-terminus or the Zinc-finger region.
Ogunkolade et al. BMC Cell Biology 2013 14:52 doi:10.1186/1471-2121-14-52