Model of caspase activation downstream of cytochrome c release during apoptosis. Cell death signals induce MOMP, which leads to cytochrome c release and the activation of caspase-9. Caspase-9 can cleave and activate Bid, caspase-7 and caspase-3. tBid can remodel the mitochondria and make conditions favorable for ROS production, which is enhanced by caspase-7 and inhibited by caspase-3.
Brentnall et al. BMC Cell Biology 2013 14:32 doi:10.1186/1471-2121-14-32