Model for impact of in vitro chronic glucolipotoxicity on cellular processes in pancreatic beta cells. Model describes the signaling pathways involved in glucose and fat metabolism with focus on their coupling to insulin secretion. We found that under chronic glucolipotoxic conditions in vitro, multiple signaling events involved in glucose and fat metabolism are dysregulated leading to impaired insulin synthesis, content and secretion. The effects of chronic glucolipotoxic conditions on the signaling events involved are shown using upward arrowheads (representing an increase) and downward arrowheads (representing a decrease). In the model, arrows indicate activation and blunt arrows indicate inhibition.
Somesh et al. BMC Cell Biology 2013 14:31 doi:10.1186/1471-2121-14-31