Rheb expression and translocation into the nucleus. Rheb activation by diverse extracellular signal enables Rheb to directly interact with mTOR. Rheb possibly binds to mTOR to shuttle between nucleus and cytoplasm or it may translocate alone to the nucleus for as yet unknown function (scheme modified from .
Yadav et al. BMC Cell Biology 2013 14:3 doi:10.1186/1471-2121-14-3