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Open Access Open Badges Research article

Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins

Chao Liu1, Haijie Ma1, Jiaxue Wu1, Qiang Huang1, Jun O Liu2 and Long Yu13*

Author Affiliations

1 State Key Laboratory of Genetic Engineering; Institute of Genetics; School of Life Sciences, Fudan University, Shanghai 200433, China

2 Departments of Pharmacology and Molecular Sciences and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

3 Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China

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BMC Cell Biology 2013, 14:27  doi:10.1186/1471-2121-14-27

Published: 30 May 2013

Additional files

Additional file 1: Table S1:

Gene Bank accession numbers of ESTs. Table S2. Allele specific primers for each transcript. Table S3. Primers used in this paper for cloning and mutagenesis. Figure S1. The sequencing results of LC3B-a, GABARAP-a and GABARAPL1-a.Figure S2. Primer specificity test for LC3B and LC3B-a transcripts. Figure S3. Alignment of human Atg8 family proteins. Figure S4. The interaction between LC3B-a and ATG4B is intact as that of LC3B. Figure S5. Cartoon representation of human ATG4B-rat LC3B complex.

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